MZT1

Entrez Summary: N/A
UniProt Summary: Required for gamma-tubulin complex recruitment to the centrosome. {ECO:0000269|PubMed:20360068}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 50/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	0/28
bone	3/26
breast	6/33
central nervous system	4/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	1/20
lung	5/75
lymphocyte	0/16
ovary	0/26
pancreas	3/24
peripheral nervous system	1/16
plasma cell	3/15
prostate	1/1
skin	2/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	3/29
uterus	1/5

Expression Distribution

gamma-tubulin complex localization
interphase microtubule organizing center
microtubule nucleation by interphase microtubule organizing center
gamma-tubulin ring complex
microtubule nucleation by microtubule organizing center
microtubule nucleation
cellular protein-containing complex localization
microtubule polymerization
mitotic spindle assembly
microtubule polymerization or depolymerization
mitotic spindle organization
protein polymerization
spindle assembly
microtubule cytoskeleton organization involved in mitosis
spindle
mitotic nuclear division
spindle organization
protein-containing complex localization
nuclear division
organelle fission
supramolecular fiber organization
microtubule cytoskeleton organization
centrosome
mitotic cell cycle process
microtubule-based process
mitotic cell cycle
organelle assembly
cellular protein-containing complex assembly
cell cycle process
cytoskeleton organization
cell cycle
protein-containing complex assembly
cellular protein localization
cellular macromolecule localization
protein-containing complex subunit organization