NAA15 [The Human Chemical-Genetic Interaction Map Project]

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======= NAA15 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AA15
  * **<color #00a2e8>Official Name</color>**: N-alpha-acetyltransferase 15, NatA auxiliary subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80155|80155]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXJ9|Q9BXJ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAA15&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAA15|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608000|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. {ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15496142}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NARP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NatA complex|
|N-terminal peptidyl-methionine acetylation|
|peptide alpha-N-acetyltransferase activity|
|peptidyl-methionine modification|
|N-terminal protein amino acid acetylation|
|acetyltransferase activity|
|N-terminal protein amino acid modification|
|ribosome binding|
|protein acetylation|
|protein stabilization|
|protein acylation|
|transcription factor complex|
|protein maturation|
|regulation of protein stability|
|angiogenesis|
|blood vessel morphogenesis|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|tube morphogenesis|
|tube development|
|circulatory system development|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|RNA binding|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.14|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-2.02|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.99|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.9|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.83|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.83|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.83|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.81|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.76|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.73|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.75|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.76|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.87|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.98|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.99|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.03|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|2.12|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.21|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.25|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.37|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.4|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.4|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.44|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.45|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.48|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|3.12|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|3.31|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.32|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|4.1|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|5.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 624/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|22/28|
|blood|19/28|
|bone|20/26|
|breast|25/33|
|central nervous system|49/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|17/21|
|liver|15/20|
|lung|67/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|22/24|
|peripheral nervous system|11/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1450
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAA15 Expression in NALM6 Cells: 7.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>