NAA15

Entrez Summary: N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017].
UniProt Summary: Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter. {ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15496142}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CB-5083 0.4μM R08 exp468	-2.14
Heregulin-B 44ng/ml R08 exp486	-2.02
Ethanol 0.003 R08 exp437	-1.99
Mitomycin-C 0.06μM R08 exp503	-1.9
Bortezomib 0.005μM R00 exp6	-1.83
Hydroxyurea 100μM R07 exp329	-1.83
Oligomycin-A 2μM R00 exp25	-1.83
SNS-032 15μM R08 exp443	-1.81
THZ1 0.06μM R08 exp531	-1.76
Demecolcine 0.03μM R05 exp228	-1.73
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.75
Docosahexaenoic-acid 50μM R07 exp356	1.76
Fluvastatin 2.2μM R06 exp282	1.87
Latrunculin-B 10μM R07 exp374	1.98
5-Azacytidine 2μM R07 exp330	1.99
LB-100 2μM R05 exp210	2.03
Cyclosporin-A 0.8μM R07 exp347	2.12
Arsenic trioxide 60μM R08 exp449	2.21
MS023 7μM R03 exp135	2.25
Artemisinin 50μM R08 exp450	2.37
LB-100 4.1μM R02 exp72	2.4
ML-792 0.2μM R08 exp505	2.4
Rapamycin 2μM plus FK-506 5μM R07 exp308	2.44
JQ1 0.8μM R08 exp435	2.45
Genistein 15μM R07 exp360	2.48
Pyridostatin 4μM R05 exp240	3.12
Etoposide 0.1μM R05 exp198	3.31
I-BRD9 4μM R07 exp365	3.32
Etoposide 0.3μM R05 exp199	4.1
Doxorubicin 0.02μM R08 exp478	5.57

Global Fraction of Cell Lines Where Essential: 624/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	22/28
blood	19/28
bone	20/26
breast	25/33
central nervous system	49/56
cervix	4/4
colorectal	13/17
esophagus	13/13
fibroblast	1/1
gastric	12/16
kidney	17/21
liver	15/20
lung	67/75
lymphocyte	16/16
ovary	24/26
pancreas	22/24
peripheral nervous system	11/16
plasma cell	14/15
prostate	1/1
skin	18/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	19/22
urinary tract	28/29
uterus	5/5

Expression Distribution

NatA complex
N-terminal peptidyl-methionine acetylation
peptide alpha-N-acetyltransferase activity
peptidyl-methionine modification
N-terminal protein amino acid acetylation
acetyltransferase activity
N-terminal protein amino acid modification
ribosome binding
protein acetylation
protein stabilization
protein acylation
transcription factor complex
protein maturation
regulation of protein stability
angiogenesis
blood vessel morphogenesis
blood vessel development
vasculature development
cardiovascular system development
tube morphogenesis
tube development
circulatory system development
peptidyl-amino acid modification
negative regulation of apoptotic process
anatomical structure formation involved in morphogenesis
negative regulation of programmed cell death
negative regulation of cell death
RNA binding
regulation of apoptotic process
positive regulation of transcription, DNA-templated
regulation of programmed cell death
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
regulation of cell death
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
membrane