NAGLU [The Human Chemical-Genetic Interaction Map Project]

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======= NAGLU =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AGLU
  * **<color #00a2e8>Official Name</color>**: N-acetyl-alpha-glucosaminidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4669|4669]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54802|P54802]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAGLU&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAGLU|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609701|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the degradation of heparan sulfate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAGLU|
|NAGLU C|
|NAGLU N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alpha-N-acetylglucosaminidase activity|
|retinal rod cell development|
|locomotor rhythm|
|middle ear morphogenesis|
|circadian behavior|
|rhythmic behavior|
|cerebellar Purkinje cell layer development|
|eye photoreceptor cell development|
|inner ear receptor cell development|
|eye photoreceptor cell differentiation|
|photoreceptor cell development|
|cerebellar cortex development|
|inner ear receptor cell differentiation|
|photoreceptor cell differentiation|
|mechanoreceptor differentiation|
|lysosome organization|
|lytic vacuole organization|
|glycosaminoglycan catabolic process|
|aminoglycan catabolic process|
|lysosomal lumen|
|cerebellum development|
|metencephalon development|
|ear morphogenesis|
|vacuole organization|
|circadian rhythm|
|eye morphogenesis|
|hindbrain development|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|carbohydrate derivative catabolic process|
|inner ear development|
|locomotory behavior|
|ear development|
|lysosome|
|sensory organ morphogenesis|
|rhythmic process|
|embryonic organ morphogenesis|
|eye development|
|visual system development|
|sensory system development|
|embryonic organ development|
|sensory organ development|
|embryonic morphogenesis|
|behavior|
|brain development|
|head development|
|neuron development|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|neuron differentiation|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|generation of neurons|
|neurogenesis|
|cell development|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.74|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.83|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.89|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6432
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAGLU Expression in NALM6 Cells: 4.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>