NAGLU

Entrez Summary: This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008].
UniProt Summary: Involved in the degradation of heparan sulfate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

alpha-N-acetylglucosaminidase activity
retinal rod cell development
locomotor rhythm
middle ear morphogenesis
circadian behavior
rhythmic behavior
cerebellar Purkinje cell layer development
eye photoreceptor cell development
inner ear receptor cell development
eye photoreceptor cell differentiation
photoreceptor cell development
cerebellar cortex development
inner ear receptor cell differentiation
photoreceptor cell differentiation
mechanoreceptor differentiation
lysosome organization
lytic vacuole organization
glycosaminoglycan catabolic process
aminoglycan catabolic process
lysosomal lumen
cerebellum development
metencephalon development
ear morphogenesis
vacuole organization
circadian rhythm
eye morphogenesis
hindbrain development
glycosaminoglycan metabolic process
aminoglycan metabolic process
carbohydrate derivative catabolic process
inner ear development
locomotory behavior
ear development
lysosome
sensory organ morphogenesis
rhythmic process
embryonic organ morphogenesis
eye development
visual system development
sensory system development