NANOS1

Entrez Summary: This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015].
UniProt Summary: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. {ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cerebellar neuron development
translation repressor activity
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of mRNA catabolic process
positive regulation of mRNA metabolic process
central nervous system neuron development
epithelial cell migration
epithelium migration
tissue migration
cerebellum development
metencephalon development
negative regulation of translation
negative regulation of cellular amide metabolic process
hindbrain development
ameboidal-type cell migration
central nervous system neuron differentiation
tissue homeostasis
regulation of mRNA catabolic process
multicellular organismal homeostasis
regulation of mRNA metabolic process
anatomical structure homeostasis
regulation of translation
positive regulation of cellular catabolic process
regulation of cellular amide metabolic process
regulation of cell growth
positive regulation of catabolic process
posttranscriptional regulation of gene expression
regulation of growth
perinuclear region of cytoplasm
brain development
head development
neuron development
regulation of cellular catabolic process
zinc ion binding
cell migration
central nervous system development
regulation of catabolic process
neuron differentiation
negative regulation of cellular protein metabolic process