NANOS2

Gene Information

Official Symbol: N/ANOS2
Official Name: nanos C2HC-type zinc finger 2
Aliases and Previous Symbols: N/A
Entrez ID: 339345
UniProt: P60321
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11772
Expression level (log2 read counts): -6.6

Expression Distribution

germ-line stem cell population maintenance
negative regulation of meiotic nuclear division
negative regulation of meiotic cell cycle
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of meiotic nuclear division
negative regulation of nuclear division
positive regulation of mRNA catabolic process
regulation of meiotic cell cycle
negative regulation of reproductive process
positive regulation of mRNA metabolic process
P-body
negative regulation of translation
stem cell population maintenance
maintenance of cell number
negative regulation of cellular amide metabolic process
regulation of reproductive process
mRNA binding
regulation of nuclear division
regulation of mRNA catabolic process
mRNA catabolic process
RNA catabolic process
negative regulation of cell cycle process
regulation of mRNA metabolic process
regulation of translation
positive regulation of cellular catabolic process
negative regulation of organelle organization
nucleobase-containing compound catabolic process
regulation of cellular amide metabolic process
positive regulation of catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
posttranscriptional regulation of gene expression
spermatogenesis
male gamete generation
negative regulation of cell cycle
gamete generation
mRNA metabolic process