NAP1L2 [The Human Chemical-Genetic Interaction Map Project]

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======= NAP1L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AP1L2
  * **<color #00a2e8>Official Name</color>**: nucleosome assembly protein 1 like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4674|4674]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULW6|Q9ULW6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAP1L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAP1L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300026|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this intronless gene is a member of the nucleosome assembly protein (NAP) family. The encoded protein represents a class of tissue-specific factors that interact with chromatin to regulate neuronal cell proliferation. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acidic protein which may be involved in interactions with other proteins or DNA. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of histone H3-K14 acetylation|
|regulation of histone H3-K14 acetylation|
|positive regulation of histone H3-K9 acetylation|
|regulation of stem cell division|
|regulation of histone H3-K9 acetylation|
|positive regulation of histone acetylation|
|positive regulation of peptidyl-lysine acetylation|
|positive regulation of protein acetylation|
|regulation of histone acetylation|
|regulation of peptidyl-lysine acetylation|
|regulation of protein acetylation|
|positive regulation of histone modification|
|positive regulation of chromatin organization|
|nucleosome assembly|
|histone binding|
|chromatin assembly|
|regulation of histone modification|
|chromatin assembly or disassembly|
|nucleosome organization|
|regulation of cell division|
|positive regulation of chromosome organization|
|DNA packaging|
|regulation of chromatin organization|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|DNA conformation change|
|regulation of chromosome organization|
|positive regulation of neuron differentiation|
|chromatin binding|
|positive regulation of neurogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|chromatin organization|
|regulation of neurogenesis|
|cellular protein-containing complex assembly|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|chromosome organization|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|positive regulation of developmental process|
|generation of neurons|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.83|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.8|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/25|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/14|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18385
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAP1L2 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>