NAPB

Entrez Summary: This gene encodes a member of the soluble N-ethyl-maleimide-sensitive fusion attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. This gene encodes the SNAP beta isoform which has been shown to be preferentially expressed in brain tissue. The encoded protein also interacts with the GluR2 alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit C-terminus and may play a role as a chaperone in the molecular processing of the AMPA receptor. [provided by RefSeq, Mar 2017].
UniProt Summary: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

SNARE complex disassembly
soluble NSF attachment protein activity
synaptobrevin 2-SNAP-25-syntaxin-1a complex
regulation of synaptic vesicle priming
vacuolar membrane
synaptic transmission, glutamatergic
SNARE complex
syntaxin binding
regulation of synaptic vesicle exocytosis
regulation of neurotransmitter secretion
regulation of synaptic vesicle cycle
cellular protein complex disassembly
regulation of neurotransmitter transport
regulation of regulated secretory pathway
regulation of exocytosis
protein-containing complex disassembly
regulation of neurotransmitter levels
cellular component disassembly
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
modulation of chemical synaptic transmission
regulation of trans-synaptic signaling
regulation of protein complex assembly
synaptic signaling
regulation of vesicle-mediated transport
regulation of secretion by cell
regulation of secretion
regulation of cellular localization
regulation of cellular component biogenesis
intracellular protein transport
cell-cell signaling
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell