NAPEPLD [The Human Chemical-Genetic Interaction Map Project]

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======= NAPEPLD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/APEPLD
  * **<color #00a2e8>Official Name</color>**: N-acyl phosphatidylethanolamine phospholipase D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=222236|222236]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6IQ20|Q6IQ20]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAPEPLD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAPEPLD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612334|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lactamase B 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|host-mediated regulation of intestinal microbiota composition|
|N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity|
|membrane-bounded organelle|
|negative regulation of eating behavior|
|N-acylethanolamine metabolic process|
|N-acylphosphatidylethanolamine-specific phospholipase D activity|
|response to isolation stress|
|N-acylphosphatidylethanolamine metabolic process|
|regulation of eating behavior|
|ethanolamine-containing compound metabolic process|
|positive regulation of brown fat cell differentiation|
|negative regulation of feeding behavior|
|regulation of brown fat cell differentiation|
|negative regulation of behavior|
|photoreceptor outer segment membrane|
|phosphatidylethanolamine metabolic process|
|regulation of feeding behavior|
|temperature homeostasis|
|phospholipid catabolic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|positive regulation of fat cell differentiation|
|amine metabolic process|
|modification by host of symbiont morphology or physiology|
|regulation of behavior|
|interaction with symbiont|
|primary alcohol metabolic process|
|retinoid metabolic process|
|diterpenoid metabolic process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|terpenoid metabolic process|
|regulation of fat cell differentiation|
|organophosphate catabolic process|
|isoprenoid metabolic process|
|positive regulation of inflammatory response|
|early endosome membrane|
|modification of morphology or physiology of other organism|
|nuclear envelope|
|cellular lipid catabolic process|
|homeostasis of number of cells|
|early endosome|
|aging|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|multicellular organismal homeostasis|
|regulation of inflammatory response|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic hydroxy compound metabolic process|
|positive regulation of defense response|
|positive regulation of response to external stimulus|
|Golgi membrane|
|regulation of defense response|
|symbiotic process|
|cellular amide metabolic process|
|interspecies interaction between organisms|
|zinc ion binding|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|Golgi apparatus|
|identical protein binding|
|regulation of response to external stimulus|
|lipid metabolic process|
|positive regulation of developmental process|
|regulation of response to stress|
|homeostatic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.72|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12366
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAPEPLD Expression in NALM6 Cells: 4.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>