NAPEPLD

Gene Information

Official Symbol: N/APEPLD
Official Name: N-acyl phosphatidylethanolamine phospholipase D
Aliases and Previous Symbols: N/A
Entrez ID: 222236
UniProt: Q6IQ20
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N- arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12366
Expression level (log2 read counts): 4.95

Expression Distribution

Screen	Score
Rotenone 20μM R00 exp34	1.72
Oligomycin-A 2μM R00 exp25	1.78

host-mediated regulation of intestinal microbiota composition
N-acetylphosphatidylethanolamine-hydrolysing phospholipase activity
membrane-bounded organelle
negative regulation of eating behavior
N-acylethanolamine metabolic process
N-acylphosphatidylethanolamine-specific phospholipase D activity
response to isolation stress
N-acylphosphatidylethanolamine metabolic process
regulation of eating behavior
ethanolamine-containing compound metabolic process
positive regulation of brown fat cell differentiation
negative regulation of feeding behavior
regulation of brown fat cell differentiation
negative regulation of behavior
photoreceptor outer segment membrane
phosphatidylethanolamine metabolic process
regulation of feeding behavior
temperature homeostasis
phospholipid catabolic process
cellular biogenic amine metabolic process
cellular amine metabolic process
positive regulation of fat cell differentiation
amine metabolic process
modification by host of symbiont morphology or physiology
regulation of behavior
interaction with symbiont
primary alcohol metabolic process
retinoid metabolic process
diterpenoid metabolic process
modification of morphology or physiology of other organism involved in symbiotic interaction
terpenoid metabolic process
regulation of fat cell differentiation
organophosphate catabolic process
isoprenoid metabolic process
positive regulation of inflammatory response
early endosome membrane
modification of morphology or physiology of other organism
nuclear envelope
cellular lipid catabolic process
homeostasis of number of cells