NCAM1 [The Human Chemical-Genetic Interaction Map Project]

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======= NCAM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCAM1
  * **<color #00a2e8>Official Name</color>**: neural cell adhesion molecule 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4684|4684]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13591|P13591]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCAM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCAM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/116930|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|fn3|
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of semaphorin-plexin signaling pathway|
|commissural neuron axon guidance|
|interferon-gamma-mediated signaling pathway|
|virus receptor activity|
|viral entry into host cell|
|anchored component of membrane|
|entry into host cell|
|entry into host|
|interaction with host|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|viral life cycle|
|axon guidance|
|neuron projection guidance|
|collagen-containing extracellular matrix|
|axonogenesis|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|external side of plasma membrane|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|cell surface|
|Golgi membrane|
|neuron projection development|
|cytokine-mediated signaling pathway|
|viral process|
|cell morphogenesis|
|innate immune response|
|symbiotic process|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|protein phosphorylation|
|cellular response to cytokine stimulus|
|neuron differentiation|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7243
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCAM1 Expression in NALM6 Cells: 0.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>