NCKIPSD [The Human Chemical-Genetic Interaction Map Project]

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======= NCKIPSD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCKIPSD
  * **<color #00a2e8>Official Name</color>**: NCK interacting protein with SH3 domain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51517|51517]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZQ3|Q9NZQ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCKIPSD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCKIPSD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606671|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP- induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2013|
|SH3 1|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COP9 signalosome|
|cytoskeletal protein binding|
|intermediate filament|
|SH3 domain binding|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|Fc receptor signaling pathway|
|positive regulation of neuron projection development|
|phagocytosis|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of neurogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|activation of immune response|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|positive regulation of immune response|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|immune effector process|
|cytoskeleton organization|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.78|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.92|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6283
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCKIPSD Expression in NALM6 Cells: 4.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>