NCKIPSD

Gene Information

Official Symbol: NCKIPSD
Official Name: NCK interacting protein with SH3 domain
Aliases and Previous Symbols: N/A
Entrez ID: 51517
UniProt: Q9NZQ3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP- induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6283
Expression level (log2 read counts): 4.74

Expression Distribution

Screen	Score
Rapamycin 2μM plus FK-506 5μM R07 exp308	1.78
LB-100 2μM R05 exp210	1.92
Etoposide 0.3μM R05 exp199	2.16

DUF2013
SH3 1
SH3 2

COP9 signalosome
cytoskeletal protein binding
intermediate filament
SH3 domain binding
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc-gamma receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
Fc receptor signaling pathway
positive regulation of neuron projection development
phagocytosis
positive regulation of neuron differentiation
positive regulation of cell projection organization
immune response-activating cell surface receptor signaling pathway
positive regulation of neurogenesis
immune response-regulating cell surface receptor signaling pathway
regulation of neuron projection development
positive regulation of nervous system development
positive regulation of cell development
immune response-activating signal transduction
immune response-regulating signaling pathway
activation of immune response
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of neurogenesis
positive regulation of immune response
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
immune effector process
cytoskeleton organization
positive regulation of immune system process
regulation of immune response
positive regulation of cellular component organization
positive regulation of developmental process
generation of neurons
neurogenesis
regulation of immune system process
positive regulation of multicellular organismal process