NCOA1 [The Human Chemical-Genetic Interaction Map Project]

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======= NCOA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCOA1
  * **<color #00a2e8>Official Name</color>**: nuclear receptor coactivator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8648|8648]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15788|Q15788]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCOA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCOA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602691|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRC-1|
|DUF1518|
|Nuc rec co-act|
|PAS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of transcription by galactose|
|positive regulation of transcription by galactose|
|positive regulation of transcription from RNA polymerase II promoter by galactose|
|regulation of transcription from RNA polymerase II promoter by galactose|
|cellular response to Thyroglobulin triiodothyronine|
|progesterone receptor binding|
|positive regulation of female receptivity|
|carbon catabolite regulation of transcription from RNA polymerase II promoter|
|response to Thyroglobulin triiodothyronine|
|carbon catabolite activation of transcription from RNA polymerase II promoter|
|regulation of thyroid hormone mediated signaling pathway|
|carbon catabolite activation of transcription|
|carbon catabolite regulation of transcription|
|male mating behavior|
|regulation of female receptivity|
|aryl hydrocarbon receptor binding|
|female mating behavior|
|RNA polymerase II regulatory region DNA binding|
|estrous cycle|
|retinoid X receptor binding|
|nuclear receptor binding|
|mating behavior|
|labyrinthine layer morphogenesis|
|hypothalamus development|
|nuclear hormone receptor binding|
|embryonic placenta morphogenesis|
|bile acid and bile salt transport|
|reproductive behavior|
|mating|
|regulation of cellular response to drug|
|androgen receptor signaling pathway|
|estrogen receptor binding|
|androgen receptor binding|
|lactation|
|response to progesterone|
|labyrinthine layer development|
|histone acetyltransferase activity|
|histone H4 acetylation|
|nuclear receptor transcription coactivator activity|
|ovulation cycle|
|cellular response to nutrient|
|intracellular steroid hormone receptor signaling pathway|
|body fluid secretion|
|diencephalon development|
|hippocampus development|
|embryonic placenta development|
|regulation of response to drug|
|cerebellum development|
|protein N-terminus binding|
|response to retinoic acid|
|limbic system development|
|metencephalon development|
|histone acetylation|
|cerebral cortex development|
|internal peptidyl-lysine acetylation|
|steroid hormone mediated signaling pathway|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|mammary gland development|
|male gonad development|
|development of primary male sexual characteristics|
|response to estradiol|
|monocarboxylic acid transport|
|organic hydroxy compound transport|
|protein acetylation|
|hindbrain development|
|placenta development|
|male sex differentiation|
|protein dimerization activity|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|pallium development|
|cellular response to steroid hormone stimulus|
|protein acylation|
|response to ketone|
|gonad development|
|response to nutrient|
|development of primary sexual characteristics|
|cellular response to nutrient levels|
|nuclear chromatin|
|telencephalon development|
|cellular response to extracellular stimulus|
|sex differentiation|
|protein-containing complex binding|
|rhythmic process|
|transcription coactivator activity|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|peptidyl-lysine modification|
|lipid localization|
|neuron projection|
|response to steroid hormone|
|cellular response to external stimulus|
|response to acid chemical|
|enzyme binding|
|histone modification|
|positive regulation of neuron differentiation|
|covalent chromatin modification|
|in utero embryonic development|
|forebrain development|
|chromatin binding|
|regulation of lipid metabolic process|
|gland development|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|organic anion transport|
|positive regulation of neurogenesis|
|regulation of body fluid levels|
|response to nutrient levels|
|cellular response to lipid|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|embryonic morphogenesis|
|behavior|
|anion transport|
|protein-containing complex|
|cellular response to hormone stimulus|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|positive regulation of cell death|
|chromatin organization|
|brain development|
|head development|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|peptidyl-amino acid modification|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|multi-organism reproductive process|
|response to drug|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|ion transport|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.28|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.87|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.73|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.7|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.74|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.94|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18382
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCOA1 Expression in NALM6 Cells: 4.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>