NCOA6

Entrez Summary: N/A
UniProt Summary: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glucocorticoid receptor signaling pathway
corticosteroid receptor signaling pathway
retinoid X receptor binding
intracellular estrogen receptor signaling pathway
thyroid hormone receptor binding
histone methyltransferase complex
estrogen receptor binding
nuclear receptor transcription coactivator activity
intracellular steroid hormone receptor signaling pathway
steroid hormone mediated signaling pathway
intracellular receptor signaling pathway
hormone-mediated signaling pathway
cellular response to steroid hormone stimulus
transcription factor complex
DNA replication
DNA-templated transcription, initiation
myeloid cell differentiation
DNA recombination
transcription coactivator activity
response to steroid hormone
enzyme binding
chromatin binding
regulation of lipid metabolic process
DNA repair
cellular response to lipid
heart development
cellular response to organic cyclic compound
hemopoiesis
cellular response to hormone stimulus
hematopoietic or lymphoid organ development
transcription, DNA-templated
nucleic acid-templated transcription
immune system development
RNA biosynthetic process
intracellular membrane-bounded organelle
brain development
DNA metabolic process
cellular response to DNA damage stimulus
head development
response to lipid