NDFIP2 [The Human Chemical-Genetic Interaction Map Project]

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======= NDFIP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDFIP2
  * **<color #00a2e8>Official Name</color>**: Nedd4 family interacting protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54602|54602]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NV92|Q9NV92]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDFIP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDFIP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610041|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q91ZP6, ECO:0000269|PubMed:12761501, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:20534535, ECO:0000269|PubMed:26363003}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2370|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|multivesicular body membrane|
|WW domain binding|
|negative regulation of transporter activity|
|positive regulation of protein ubiquitination|
|positive regulation of protein modification by small protein conjugation or removal|
|vacuolar transport|
|negative regulation of protein transport|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of establishment of protein localization|
|regulation of protein ubiquitination|
|regulation of protein modification by small protein conjugation or removal|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of transporter activity|
|negative regulation of transport|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|Golgi membrane|
|metal ion transport|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|cation transport|
|cellular macromolecule catabolic process|
|Golgi apparatus|
|endoplasmic reticulum|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|mitochondrion|
|proteolysis|
|ion transport|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.11|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.77|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.7|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.71|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6197
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDFIP2 Expression in NALM6 Cells: -0.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>