NDFIP2

Entrez Summary: N/A
UniProt Summary: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q91ZP6, ECO:0000269|PubMed:12761501, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:20534535, ECO:0000269|PubMed:26363003}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

multivesicular body membrane
WW domain binding
negative regulation of transporter activity
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
vacuolar transport
negative regulation of protein transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of establishment of protein localization
regulation of protein ubiquitination
regulation of protein modification by small protein conjugation or removal
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of transporter activity
negative regulation of transport
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
Golgi membrane
metal ion transport
protein catabolic process
intracellular membrane-bounded organelle
perinuclear region of cytoplasm
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
cation transport
cellular macromolecule catabolic process
Golgi apparatus
endoplasmic reticulum
positive regulation of intracellular signal transduction
regulation of protein localization
macromolecule catabolic process
organonitrogen compound catabolic process
negative regulation of molecular function
positive regulation of protein modification process
mitochondrion
proteolysis
ion transport