NDNF [The Human Chemical-Genetic Interaction Map Project]

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======= NDNF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDNF
  * **<color #00a2e8>Official Name</color>**: neuron derived neurotrophic factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79625|79625]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TB73|Q8TB73]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDNF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDNF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616506|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth and survival as well as neurite outgrowth (PubMed:20969804). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764). {ECO:0000250|UniProtKB:Q8C119, ECO:0000269|PubMed:20969804, ECO:0000269|PubMed:24706764}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2369|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vascular wound healing|
|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|
|angiogenesis involved in wound healing|
|nitric oxide mediated signal transduction|
|glycosaminoglycan binding|
|negative regulation of endothelial cell apoptotic process|
|chondroitin sulfate metabolic process|
|negative regulation of epithelial cell apoptotic process|
|chondroitin sulfate proteoglycan metabolic process|
|response to ischemia|
|regulation of endothelial cell apoptotic process|
|peptide cross-linking|
|regulation of epithelial cell apoptotic process|
|proteoglycan metabolic process|
|mucopolysaccharide metabolic process|
|neuron migration|
|positive regulation of cell-substrate adhesion|
|negative regulation of neuron apoptotic process|
|glycosaminoglycan metabolic process|
|aminoglycan metabolic process|
|heparin binding|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|peptidyl-serine modification|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|regulation of cell-substrate adhesion|
|cellular response to oxygen levels|
|extracellular matrix|
|positive regulation of neuron projection development|
|regulation of neuron death|
|angiogenesis|
|second-messenger-mediated signaling|
|extracellular matrix organization|
|response to hypoxia|
|response to decreased oxygen levels|
|sulfur compound metabolic process|
|positive regulation of neuron differentiation|
|response to oxygen levels|
|positive regulation of cell projection organization|
|glycoprotein metabolic process|
|extracellular structure organization|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|positive regulation of neurogenesis|
|wound healing|
|blood vessel development|
|regulation of neuron projection development|
|vasculature development|
|cardiovascular system development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|response to wounding|
|tube morphogenesis|
|regulation of neuron differentiation|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|tube development|
|circulatory system development|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|positive regulation of cell differentiation|
|negative regulation of cell death|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|localization of cell|
|cell motility|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|locomotion|
|positive regulation of developmental process|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|neurogenesis|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6083
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDNF Expression in NALM6 Cells: -1.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>