NDNF

Entrez Summary: N/A
UniProt Summary: Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth and survival as well as neurite outgrowth (PubMed:20969804). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764). {ECO:0000250|UniProtKB:Q8C119, ECO:0000269|PubMed:20969804, ECO:0000269|PubMed:24706764}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vascular wound healing
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
angiogenesis involved in wound healing
nitric oxide mediated signal transduction
glycosaminoglycan binding
negative regulation of endothelial cell apoptotic process
chondroitin sulfate metabolic process
negative regulation of epithelial cell apoptotic process
chondroitin sulfate proteoglycan metabolic process
response to ischemia
regulation of endothelial cell apoptotic process
peptide cross-linking
regulation of epithelial cell apoptotic process
proteoglycan metabolic process
mucopolysaccharide metabolic process
neuron migration
positive regulation of cell-substrate adhesion
negative regulation of neuron apoptotic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
heparin binding
cellular response to hypoxia
cellular response to decreased oxygen levels
peptidyl-serine modification
regulation of neuron apoptotic process
negative regulation of neuron death
regulation of cell-substrate adhesion
cellular response to oxygen levels
extracellular matrix
positive regulation of neuron projection development
regulation of neuron death
angiogenesis
second-messenger-mediated signaling
extracellular matrix organization
response to hypoxia
response to decreased oxygen levels
sulfur compound metabolic process
positive regulation of neuron differentiation
response to oxygen levels
positive regulation of cell projection organization