NDOR1 [The Human Chemical-Genetic Interaction Map Project]

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======= NDOR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDOR1
  * **<color #00a2e8>Official Name</color>**: N/ADPH dependent diflavin oxidoreductase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27158|27158]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHB4|Q9UHB4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDOR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDOR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606073|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:10625700, ECO:0000269|PubMed:20802492, ECO:0000269|PubMed:23596212}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAD binding 1|
|FAD binding 1|
|Flavodoxin 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to menadione|
|NADPH-hemoprotein reductase activity|
|FMN binding|
|metallo-sulfur cluster assembly|
|iron-sulfur cluster assembly|
|NADP binding|
|intermediate filament cytoskeleton|
|flavin adenine dinucleotide binding|
|cellular response to ketone|
|oxidoreductase activity|
|response to ketone|
|cofactor biosynthetic process|
|sulfur compound metabolic process|
|cellular response to drug|
|cofactor metabolic process|
|perinuclear region of cytoplasm|
|oxidation-reduction process|
|response to drug|
|cellular response to oxygen-containing compound|
|cell death|
|response to oxygen-containing compound|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-2.06|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gemin8|GEMIN8]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 411/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|8/28|
|bone|14/26|
|breast|23/33|
|central nervous system|41/56|
|cervix|2/4|
|colorectal|7/17|
|esophagus|6/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|17/21|
|liver|12/20|
|lung|40/75|
|lymphocyte|7/16|
|ovary|20/26|
|pancreas|10/24|
|peripheral nervous system|6/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|14/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|6/22|
|urinary tract|13/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 97
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDOR1 Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>