NDOR1

Entrez Summary: N/A
UniProt Summary: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:10625700, ECO:0000269|PubMed:20802492, ECO:0000269|PubMed:23596212}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 411/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	16/28
blood	8/28
bone	14/26
breast	23/33
central nervous system	41/56
cervix	2/4
colorectal	7/17
esophagus	6/13
fibroblast	1/1
gastric	10/16
kidney	17/21
liver	12/20
lung	40/75
lymphocyte	7/16
ovary	20/26
pancreas	10/24
peripheral nervous system	6/16
plasma cell	11/15
prostate	1/1
skin	14/24
soft tissue	5/9
thyroid	2/2
upper aerodigestive	6/22
urinary tract	13/29
uterus	3/5

Expression Distribution

Screen	Score
Prochlorperazine 5.2μM R02 exp77	-2.06
AICAR 240μM R05 exp211	-2.04

cellular response to menadione
NADPH-hemoprotein reductase activity
FMN binding
metallo-sulfur cluster assembly
iron-sulfur cluster assembly
NADP binding
intermediate filament cytoskeleton
flavin adenine dinucleotide binding
cellular response to ketone
oxidoreductase activity
response to ketone
cofactor biosynthetic process
sulfur compound metabolic process
cellular response to drug
cofactor metabolic process
perinuclear region of cytoplasm
oxidation-reduction process
response to drug
cellular response to oxygen-containing compound
cell death
response to oxygen-containing compound