NDUFA4

Entrez Summary: The protein encoded by this gene belongs to the complex I 9kDa subunit family. Mammalian complex I of mitochondrial respiratory chain is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008].
UniProt Summary: Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance. {ECO:0000269|PubMed:22902835}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	2/28
bone	1/26
breast	1/33
central nervous system	0/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Temozolomide 200μM R04 exp189	1.75
Oligomycin-A 2μM R00 exp25	2.05

Gene	Correlation
COX18	0.437
PET117	0.417

mitochondrial respiratory chain complex IV
aerobic electron transport chain
mitochondrial electron transport, cytochrome c to oxygen
cytochrome-c oxidase activity
NADH dehydrogenase (ubiquinone) activity
mitochondrial electron transport, NADH to ubiquinone
mitochondrial respiratory chain complex I
aerobic respiration
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
respiratory electron transport chain
oxidative phosphorylation
proton transmembrane transport
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
protein-containing complex binding
mitochondrial inner membrane
monovalent inorganic cation transport
generation of precursor metabolites and energy
inorganic cation transmembrane transport
cation transmembrane transport
inorganic ion transmembrane transport
cation transport
ion transmembrane transport
oxidation-reduction process
mitochondrion
transmembrane transport
phosphorylation
ion transport