NDUFAF2

Gene Information

Official Symbol: NDUFAF2
Official Name: N/ADH:ubiquinone oxidoreductase complex assembly factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 91942
UniProt: Q8N183
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency. [provided by RefSeq, Jul 2008].
UniProt Summary: Acts as a molecular chaperone for mitochondrial complex I assembly (PubMed:16200211). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:16200211, PubMed:27626371). {ECO:0000269|PubMed:16200211, ECO:0000269|PubMed:27626371}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6402
Expression level (log2 read counts): 4.37

Expression Distribution

negative regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of insulin secretion
negative regulation of peptide hormone secretion
NADH dehydrogenase (ubiquinone) activity
regulation of insulin secretion involved in cellular response to glucose stimulus
negative regulation of hormone secretion
mitochondrial respiratory chain complex I assembly
NADH dehydrogenase complex assembly
electron transfer activity
mitochondrial respiratory chain complex assembly
respiratory electron transport chain
reactive oxygen species metabolic process
negative regulation of protein secretion
negative regulation of peptide secretion
cellular respiration
regulation of insulin secretion
negative regulation of protein transport
electron transport chain
negative regulation of establishment of protein localization
negative regulation of secretion by cell
regulation of peptide hormone secretion
negative regulation of secretion
energy derivation by oxidation of organic compounds
regulation of hormone secretion
mitochondrial inner membrane
generation of precursor metabolites and energy
mitochondrion organization
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
regulation of hormone levels
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of secretion
cellular protein-containing complex assembly
regulation of cellular localization
oxidation-reduction process
regulation of protein localization