NECAP1

Gene Information
  • Official Symbol: NECAP1
  • Official Name: NECAP endocytosis associated 1
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 25977
  • UniProt: Q8NC96
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
  • UniProt Summary: Involved in endocytosis. {ECO:0000250}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 11564
  • Expression level (log2 read counts): 5.3

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1