NEK11 [The Human Chemical-Genetic Interaction Map Project]

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======= NEK11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEK11
  * **<color #00a2e8>Official Name</color>**: NIMA related kinase 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79858|79858]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NG66|Q8NG66]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NEK11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NEK11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609779|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intra-S DNA damage checkpoint|
|histone phosphorylation|
|mitotic DNA damage checkpoint|
|mitotic DNA integrity checkpoint|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|mitotic cell cycle checkpoint|
|cell cycle checkpoint|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|negative regulation of mitotic cell cycle|
|protein serine/threonine kinase activity|
|histone modification|
|covalent chromatin modification|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|chromatin organization|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|nucleolus|
|protein phosphorylation|
|cell cycle process|
|chromosome organization|
|regulation of cell cycle|
|phosphorylation|
|cell cycle|
|ATP binding|
|intracellular signal transduction|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.15|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.03|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.99|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.91|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.86|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9200
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NEK11 Expression in NALM6 Cells: -0.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>