NEK11

Entrez Summary: This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009].
UniProt Summary: Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation. {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cytochalasin-B 5μM R07 exp349	-2.15
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2.03
Ribavirin 10μM R01 exp52	-1.99
TIC10 10μM R08 exp532	-1.91
GSK-J4 1.5μM R08 exp441	-1.86
Glyphosate 1000μM R06 exp283	1.76

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

intra-S DNA damage checkpoint
histone phosphorylation
mitotic DNA damage checkpoint
mitotic DNA integrity checkpoint
DNA damage checkpoint
DNA integrity checkpoint
mitotic cell cycle checkpoint
cell cycle checkpoint
mitotic cell cycle phase transition
cell cycle phase transition
negative regulation of mitotic cell cycle
protein serine/threonine kinase activity
histone modification
covalent chromatin modification
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
negative regulation of cell cycle
mitotic cell cycle process
regulation of mitotic cell cycle
mitotic cell cycle
chromatin organization
regulation of cell cycle process
cellular response to DNA damage stimulus
nucleolus
protein phosphorylation
cell cycle process
chromosome organization
regulation of cell cycle
phosphorylation
cell cycle
ATP binding
intracellular signal transduction
cellular response to stress