NEU4

Entrez Summary: N/A
UniProt Summary: May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids. {ECO:0000269|PubMed:14962670, ECO:0000269|PubMed:15213228}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

organelle inner membrane
exo-alpha-sialidase activity
exo-alpha-(2→6)-sialidase activity
exo-alpha-(2→8)-sialidase activity
exo-alpha-(2→3)-sialidase activity
ganglioside catabolic process
oligosaccharide catabolic process
glycosphingolipid catabolic process
glycolipid catabolic process
ceramide catabolic process
ganglioside metabolic process
glycoprotein catabolic process
sphingolipid catabolic process
membrane lipid catabolic process
oligosaccharide metabolic process
glycosphingolipid metabolic process
ceramide metabolic process
lysosomal lumen
glycolipid metabolic process
liposaccharide metabolic process
carbohydrate catabolic process
sphingolipid metabolic process
carbohydrate derivative catabolic process
cellular lipid catabolic process
membrane lipid metabolic process
lysosome
lipid catabolic process
glycoprotein metabolic process
carbohydrate metabolic process
protein catabolic process
intracellular membrane-bounded organelle
cellular amide metabolic process
cellular macromolecule catabolic process
cellular lipid metabolic process
carbohydrate derivative metabolic process
macromolecule catabolic process
organonitrogen compound catabolic process
lipid metabolic process
organic substance catabolic process
cellular catabolic process