NEUROG3

Gene Information

Official Symbol: NEUROG3
Official Name: neurogenin 3
Aliases and Previous Symbols: N/A
Entrez ID: 50674
UniProt: Q9Y4Z2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010].
UniProt Summary: Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7949
Expression level (log2 read counts): -7.68

Expression Distribution

transdifferentiation
endocrine pancreas development
chromatin DNA binding
pancreas development
peripheral nervous system development
regulation of dendrite morphogenesis
spinal cord development
endocrine system development
regulation of dendrite development
hindbrain development
protein dimerization activity
DNA-binding transcription repressor activity, RNA polymerase II-specific
positive regulation of DNA-binding transcription factor activity
transcription coactivator activity
regulation of cell morphogenesis involved in differentiation
positive regulation of neuron differentiation
forebrain development
regulation of DNA-binding transcription factor activity
DNA-binding transcription activator activity, RNA polymerase II-specific
positive regulation of neurogenesis
regulation of cell morphogenesis
regulation of neuron projection development
RNA polymerase II proximal promoter sequence-specific DNA binding
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
epithelial cell differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
brain development
head development
regulation of neurogenesis
negative regulation of transcription by RNA polymerase II
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
central nervous system development
regulation of anatomical structure morphogenesis
epithelium development
negative regulation of transcription, DNA-templated