NFAT5

Gene Information

Official Symbol: NFAT5
Official Name: nuclear factor of activated T cells 5
Aliases and Previous Symbols: N/A
Entrez ID: 10725
UniProt: O94916
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15274
Expression level (log2 read counts): 5.67

Expression Distribution

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	-2.21
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.87
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.81

calcineurin-NFAT signaling cascade
positive regulation of leukocyte adhesion to vascular endothelial cell
calcineurin-mediated signaling
regulation of leukocyte adhesion to vascular endothelial cell
nuclear transcription factor complex
inositol phosphate-mediated signaling
regulation of calcineurin-mediated signaling
regulation of calcineurin-NFAT signaling cascade
excretion
response to osmotic stress
positive regulation of NIK/NF-kappaB signaling
regulation of calcium-mediated signaling
regulation of NIK/NF-kappaB signaling
calcium-mediated signaling
cytokine production
transcription factor complex
positive regulation of leukocyte cell-cell adhesion
positive regulation of cell-cell adhesion
regulation of leukocyte cell-cell adhesion
transcription factor binding
second-messenger-mediated signaling
chromatin binding
regulation of cell-cell adhesion
positive regulation of cell adhesion
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
regulation of cell adhesion
cellular response to cytokine stimulus
positive regulation of intracellular signal transduction
nucleobase-containing compound biosynthetic process
response to cytokine
response to abiotic stimulus
heterocycle biosynthetic process
aromatic compound biosynthetic process
positive regulation of transcription by RNA polymerase II