NFIL3

Gene Information

Official Symbol: NFIL3
Official Name: nuclear factor, interleukin 3 regulated
Aliases and Previous Symbols: N/A
Entrez ID: 4783
UniProt: Q16649
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B- site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). {ECO:0000250, ECO:0000269|PubMed:1620116, ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UMK57 1μM R01 exp59	-1.86
Hippuristanol 0.12μM R08 exp488	-1.79
PNU96415E 10μM R03 exp145	1.9
Geldanamycin 0.01μM R05 exp235	1.98
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.04

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15584
Expression level (log2 read counts): 3.95

Expression Distribution

bZIP 2
Vert IL3-reg TF

cellular response to interleukin-4
response to interleukin-4
circadian rhythm
transcription corepressor activity
DNA-binding transcription repressor activity, RNA polymerase II-specific
rhythmic process
RNA polymerase II regulatory region sequence-specific DNA binding
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
negative regulation of transcription by RNA polymerase II
cellular response to cytokine stimulus
nucleobase-containing compound biosynthetic process
response to cytokine
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
negative regulation of gene expression
positive regulation of RNA metabolic process
macromolecule biosynthetic process