NGEF [The Human Chemical-Genetic Interaction Map Project]

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======= NGEF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NGEF
  * **<color #00a2e8>Official Name</color>**: neuronal guanine nucleotide exchange factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25791|25791]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N5V2|Q8N5V2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NGEF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NGEF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605991|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|RhoGEF|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of dendritic spine morphogenesis|
|negative regulation of dendritic spine development|
|negative regulation of dendrite morphogenesis|
|negative regulation of synapse organization|
|negative regulation of dendrite development|
|regulation of dendritic spine morphogenesis|
|Rho guanyl-nucleotide exchange factor activity|
|regulation of dendritic spine development|
|ephrin receptor signaling pathway|
|regulation of dendrite morphogenesis|
|regulation of postsynapse organization|
|negative regulation of cell morphogenesis involved in differentiation|
|guanyl-nucleotide exchange factor activity|
|growth cone|
|regulation of Rho protein signal transduction|
|regulation of dendrite development|
|negative regulation of neuron projection development|
|negative regulation of cell projection organization|
|regulation of synapse organization|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|regulation of Ras protein signal transduction|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|negative regulation of cell development|
|regulation of small GTPase mediated signal transduction|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|regulation of anatomical structure morphogenesis|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|G protein-coupled receptor signaling pathway|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|neurogenesis|
|regulation of cell death|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.73|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7234
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.66 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NGEF Expression in NALM6 Cells: -1.66'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>