NGEF

Gene Information

Official Symbol: NGEF
Official Name: neuronal guanine nucleotide exchange factor
Aliases and Previous Symbols: N/A
Entrez ID: 25791
UniProt: Q8N5V2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7234
Expression level (log2 read counts): -1.66

Expression Distribution

Screen	Score
Losmapimod 1μM R07 exp376	1.73
Betulinic acid 10 to 15μM on day4 R05 exp222	1.76

SH3 2
RhoGEF
SH3 1

negative regulation of dendritic spine morphogenesis
negative regulation of dendritic spine development
negative regulation of dendrite morphogenesis
negative regulation of synapse organization
negative regulation of dendrite development
regulation of dendritic spine morphogenesis
Rho guanyl-nucleotide exchange factor activity
regulation of dendritic spine development
ephrin receptor signaling pathway
regulation of dendrite morphogenesis
regulation of postsynapse organization
negative regulation of cell morphogenesis involved in differentiation
guanyl-nucleotide exchange factor activity
growth cone
regulation of Rho protein signal transduction
regulation of dendrite development
negative regulation of neuron projection development
negative regulation of cell projection organization
regulation of synapse organization
negative regulation of neuron differentiation
regulation of synapse structure or activity
regulation of Ras protein signal transduction
negative regulation of neurogenesis
regulation of cell morphogenesis involved in differentiation
negative regulation of nervous system development
negative regulation of cell development
regulation of small GTPase mediated signal transduction
regulation of GTPase activity
regulation of cell morphogenesis
regulation of neuron projection development
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
positive regulation of cell death
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
enzyme linked receptor protein signaling pathway