NGF

Gene Information

Official Symbol: NGF
Official Name: nerve growth factor
Aliases and Previous Symbols: N/A
Entrez ID: 4803
UniProt: P01138
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008].
UniProt Summary: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177). {ECO:0000269|PubMed:20164177}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8835
Expression level (log2 read counts): -7.68

Expression Distribution

nerve growth factor receptor binding
nerve growth factor processing
positive regulation of collateral sprouting
nerve growth factor signaling pathway
metalloendopeptidase inhibitor activity
neurotrophin TRK receptor signaling pathway
regulation of collateral sprouting
neurotrophin signaling pathway
peptide hormone processing
extrinsic apoptotic signaling pathway via death domain receptors
cellular response to nerve growth factor stimulus
response to nerve growth factor
activation of MAPKK activity
positive regulation of DNA binding
positive regulation of Ras protein signal transduction
positive regulation of small GTPase mediated signal transduction
phosphatidylinositol-mediated signaling
peripheral nervous system development
inositol lipid-mediated signaling
nerve development
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of axonogenesis
activation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cysteine-type endopeptidase activity
extrinsic apoptotic signaling pathway
Golgi lumen
regulation of extent of cell growth
memory
synaptic vesicle
regulation of DNA binding
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of neuron apoptotic process
positive regulation of cysteine-type endopeptidase activity
positive regulation of cell morphogenesis involved in differentiation
protein processing
growth factor activity
positive regulation of cell growth
positive regulation of developmental growth
positive regulation of endopeptidase activity
positive regulation of binding