NGFRAP1 [The Human Chemical-Genetic Interaction Map Project]

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======= NGFRAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: BEX3
  * **<color #00a2e8>Official Name</color>**: brain expressed X-linked 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27018|27018]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00994|Q00994]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NGFRAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NGFRAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300361|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BEX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nerve growth factor receptor binding|
|cysteine-type endopeptidase activator activity involved in apoptotic process|
|extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|extrinsic apoptotic signaling pathway|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|apoptotic signaling pathway|
|negative regulation of proteolysis|
|positive regulation of proteolysis|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|negative regulation of catalytic activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|identical protein binding|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.26|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.8|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16543
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NGFRAP1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>