NGFRAP1

Gene Information

Official Symbol: BEX3
Official Name: brain expressed X-linked 3
Aliases and Previous Symbols: N/A
Entrez ID: 27018
UniProt: Q00994
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16543
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Vinblastine 0.002μM R01 exp60	-2.26
Aphidicolin 0.04μM R06 exp263	-1.8
BI-2536 0.001μM R01 exp41	1.77

nerve growth factor receptor binding
cysteine-type endopeptidase activator activity involved in apoptotic process
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cysteine-type endopeptidase activity
extrinsic apoptotic signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity
positive regulation of endopeptidase activity
positive regulation of peptidase activity
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
negative regulation of peptidase activity
apoptotic signaling pathway
negative regulation of proteolysis
positive regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
regulation of proteolysis
positive regulation of hydrolase activity
negative regulation of catalytic activity
negative regulation of apoptotic process
negative regulation of programmed cell death
apoptotic process
negative regulation of cell death
negative regulation of cellular protein metabolic process
programmed cell death
identical protein binding
cell death
negative regulation of protein metabolic process
negative regulation of molecular function
regulation of hydrolase activity
positive regulation of catalytic activity
regulation of apoptotic process