NKD1

Gene Information

Official Symbol: NKD1
Official Name: NKD inhibitor of WNT signaling pathway 1
Aliases and Previous Symbols: N/A
Entrez ID: 85407
UniProt: Q969G9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. {ECO:0000269|PubMed:11752446, ECO:0000269|PubMed:15687260, ECO:0000269|PubMed:16567647}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15288
Expression level (log2 read counts): 1.78

Expression Distribution

regulation of convergent extension involved in axis elongation
positive regulation of non-canonical Wnt signaling pathway via JNK cascade
regulation of cell motility involved in somitogenic axis elongation
negative regulation of convergent extension involved in axis elongation
regulation of non-canonical Wnt signaling pathway via JNK cascade
somatic muscle development
regulation of somitogenesis
positive regulation of Wnt signaling pathway, planar cell polarity pathway
positive regulation of non-canonical Wnt signaling pathway
regulation of Wnt signaling pathway, planar cell polarity pathway
negative regulation of morphogenesis of an epithelium
protein phosphatase type 2A complex
regulation of non-canonical Wnt signaling pathway
eye photoreceptor cell differentiation
photoreceptor cell differentiation
PDZ domain binding
negative regulation of developmental growth
regulation of establishment of planar polarity
regulation of embryonic development
eye morphogenesis
negative regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
regulation of morphogenesis of an epithelium
negative regulation of Wnt signaling pathway
positive regulation of protein catabolic process
negative regulation of growth
sensory organ morphogenesis
regulation of animal organ morphogenesis
regulation of canonical Wnt signaling pathway
regulation of developmental growth
cell-cell signaling by wnt
Wnt signaling pathway
eye development
visual system development
regulation of Wnt signaling pathway
sensory system development
regulation of protein catabolic process
cell surface receptor signaling pathway involved in cell-cell signaling
positive regulation of catabolic process
muscle structure development