NKD2

Gene Information

Official Symbol: NKD2
Official Name: NKD inhibitor of WNT signaling pathway 2
Aliases and Previous Symbols: N/A
Entrez ID: 85409
UniProt: Q969F2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2680
Expression level (log2 read counts): 2.8

Expression Distribution

Golgi vesicle fusion to target membrane
myosin heavy chain binding
positive regulation of protein processing
positive regulation of protein maturation
exocytic vesicle
growth factor binding
cell periphery
positive regulation of protein localization to plasma membrane
lateral plasma membrane
positive regulation of protein localization to cell periphery
regulation of protein processing
regulation of protein maturation
vesicle fusion
organelle membrane fusion
ATPase binding
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of protein localization to plasma membrane
organelle fusion
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
regulation of protein localization to cell periphery
positive regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein localization to membrane
regulation of proteasomal ubiquitin-dependent protein catabolic process
membrane fusion
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
negative regulation of canonical Wnt signaling pathway
protein localization to plasma membrane
regulation of proteasomal protein catabolic process
regulation of protein localization to membrane
basolateral plasma membrane
negative regulation of Wnt signaling pathway
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
protein localization to cell periphery
regulation of cellular protein catabolic process
cytoplasmic vesicle
regulation of canonical Wnt signaling pathway
ubiquitin protein ligase binding