NKX2-8
Gene Information
- Official Symbol: NKX2-8
- Official Name: NK2 homeobox 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 26257
- UniProt: O15522
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
GO Terms
| double-stranded DNA binding |
| negative regulation of epithelial cell proliferation |
| liver development |
| hepaticobiliary system development |
| lung development |
| respiratory tube development |
| respiratory system development |
| regulation of epithelial cell proliferation |
| axonogenesis |
| axon development |
| gland development |
| sequence-specific DNA binding |
| cell morphogenesis involved in neuron differentiation |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| cellular component |
| neuron projection morphogenesis |
| transcription by RNA polymerase II |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| cell part morphogenesis |
| cell morphogenesis involved in differentiation |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| neuron projection development |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| cell morphogenesis |
| neuron development |
| cellular component morphogenesis |
| tube development |
| neuron differentiation |
| nucleobase-containing compound biosynthetic process |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| organic cyclic compound biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12970
- Expression level (log2 read counts): -7.68
Expression Distribution
NKX2-8 Expression in NALM6 Cells: -7.68
