NKX3-2

Entrez Summary: This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
DABN 20μM R00 exp17	-1.87
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.77

intestinal epithelial cell development
intestinal epithelial cell differentiation
middle ear morphogenesis
negative regulation of chondrocyte differentiation
negative regulation of cartilage development
spleen development
animal organ formation
columnar/cuboidal epithelial cell development
regulation of chondrocyte differentiation
regulation of cartilage development
pancreas development
columnar/cuboidal epithelial cell differentiation
ear morphogenesis
determination of left/right symmetry
determination of bilateral symmetry
specification of symmetry
embryonic skeletal system development
digestive tract development
digestive system development
epithelial cell development
ear development
skeletal system morphogenesis
DNA-binding transcription repressor activity, RNA polymerase II-specific
sensory organ morphogenesis
embryonic organ morphogenesis
sequence-specific DNA binding
embryonic organ development
pattern specification process
transcription by RNA polymerase II
skeletal system development
RNA polymerase II proximal promoter sequence-specific DNA binding
sensory organ development
embryonic morphogenesis
hematopoietic or lymphoid organ development
chordate embryonic development
transcription, DNA-templated
nucleic acid-templated transcription
immune system development
embryo development ending in birth or egg hatching
RNA biosynthetic process