NLGN4X [The Human Chemical-Genetic Interaction Map Project]

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======= NLGN4X =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NLGN4X
  * **<color #00a2e8>Official Name</color>**: neuroligin 4 X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57502|57502]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N0W4|Q8N0W4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NLGN4X&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NLGN4X|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300427|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Putative neuronal cell surface protein involved in cell- cell-interactions.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 3|
|COesterase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|symmetric, GABA-ergic, inhibitory synapse|
|asymmetric, glutamatergic, excitatory synapse|
|brainstem development|
|spanning component of membrane|
|negative regulation of excitatory postsynaptic potential|
|presynaptic membrane assembly|
|presynaptic membrane organization|
|postsynaptic membrane assembly|
|neurexin family protein binding|
|chloride ion binding|
|neuron cell-cell adhesion|
|vocalization behavior|
|postsynapse assembly|
|presynapse assembly|
|presynapse organization|
|negative regulation of nervous system process|
|postsynaptic membrane organization|
|excitatory synapse|
|membrane assembly|
|membrane biogenesis|
|modulation of excitatory postsynaptic potential|
|presynaptic endocytosis|
|synaptic vesicle endocytosis|
|social behavior|
|intraspecies interaction between organisms|
|synaptic vesicle recycling|
|cell adhesion molecule binding|
|scaffold protein binding|
|negative regulation of synaptic transmission|
|multi-organism behavior|
|postsynapse organization|
|synapse assembly|
|presynapse|
|organ growth|
|cerebellum development|
|metencephalon development|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|regulation of nervous system process|
|cell-cell junction organization|
|adult behavior|
|learning|
|hindbrain development|
|postsynaptic membrane|
|signaling receptor activity|
|cell junction organization|
|postsynaptic density|
|learning or memory|
|synapse|
|synapse organization|
|cognition|
|developmental growth|
|growth|
|dendrite|
|regulation of membrane potential|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|cell-cell adhesion|
|cell junction|
|endocytosis|
|behavior|
|regulation of system process|
|cell surface|
|import into cell|
|brain development|
|head development|
|membrane organization|
|protein homodimerization activity|
|cell adhesion|
|biological adhesion|
|central nervous system development|
|neuron differentiation|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|negative regulation of response to stimulus|
|neurogenesis|
|establishment of localization in cell|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15313
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NLGN4X Expression in NALM6 Cells: -1.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>