NLGN4Y [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= NLGN4Y =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NLGN4Y
  * **<color #00a2e8>Official Name</color>**: neuroligin 4 Y-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22829|22829]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFZ3|Q8NFZ3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NLGN4Y&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NLGN4Y|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/400028|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a type I membrane protein that belongs to the family of neuroligins, which are cell adhesion molecules present at the postsynaptic side of the synapse, and may be essential for the formation of functional synapses. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Putative neuronal cell surface protein involved in cell- cell-interactions.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 3|
|COesterase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|symmetric, GABA-ergic, inhibitory synapse|
|asymmetric, glutamatergic, excitatory synapse|
|spanning component of membrane|
|presynaptic membrane assembly|
|presynaptic membrane organization|
|postsynaptic membrane assembly|
|neurexin family protein binding|
|neuron cell-cell adhesion|
|vocalization behavior|
|presynapse assembly|
|postsynapse assembly|
|presynapse organization|
|postsynaptic membrane organization|
|membrane assembly|
|membrane biogenesis|
|synaptic vesicle endocytosis|
|presynaptic endocytosis|
|intraspecies interaction between organisms|
|synaptic vesicle recycling|
|social behavior|
|cell adhesion molecule binding|
|scaffold protein binding|
|multi-organism behavior|
|postsynapse organization|
|synapse assembly|
|presynapse|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|learning|
|postsynaptic membrane|
|signaling receptor activity|
|postsynaptic density|
|learning or memory|
|synapse|
|synapse organization|
|cognition|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|cell-cell adhesion|
|cell junction|
|endocytosis|
|behavior|
|cell surface|
|import into cell|
|membrane organization|
|cell adhesion|
|biological adhesion|
|nervous system process|
|integral component of plasma membrane|
|establishment of localization in cell|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.75|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17134
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NLGN4Y Expression in NALM6 Cells: 0.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>