NLRC4 [The Human Chemical-Genetic Interaction Map Project]

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======= NLRC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NLRC4
  * **<color #00a2e8>Official Name</color>**: NLR family CARD domain containing 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58484|58484]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPP4|Q9NPP4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NLRC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NLRC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606831|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. {ECO:0000269|PubMed:15107016}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CARD|
|NACHT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|IPAF inflammasome complex|
|interleukin-1 beta secretion|
|pyroptosis|
|interleukin-1 secretion|
|detection of bacterium|
|detection of other organism|
|interleukin-1 beta production|
|interleukin-1 production|
|detection of external biotic stimulus|
|detection of biotic stimulus|
|cytokine secretion|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cytokine production|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of NF-kappaB transcription factor activity|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|positive regulation of endopeptidase activity|
|peptide secretion|
|positive regulation of peptidase activity|
|magnesium ion binding|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of cysteine-type endopeptidase activity|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|defense response to bacterium|
|protein homooligomerization|
|positive regulation of innate immune response|
|positive regulation of proteolysis|
|positive regulation of response to biotic stimulus|
|regulation of endopeptidase activity|
|regulation of DNA-binding transcription factor activity|
|regulation of peptidase activity|
|regulation of innate immune response|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of multi-organism process|
|protein complex oligomerization|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|activation of immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|response to bacterium|
|detection of stimulus|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|positive regulation of immune response|
|protein homodimerization activity|
|apoptotic process|
|defense response to other organism|
|secretion by cell|
|export from cell|
|programmed cell death|
|identical protein binding|
|cell death|
|regulation of response to external stimulus|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|regulation of response to stress|
|ATP binding|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.74|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.79|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15431
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NLRC4 Expression in NALM6 Cells: -0.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>