NLRC4

Gene Information

Official Symbol: NLRC4
Official Name: NLR family CARD domain containing 4
Aliases and Previous Symbols: N/A
Entrez ID: 58484
UniProt: Q9NPP4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
UniProt Summary: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. {ECO:0000269|PubMed:15107016}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15431
Expression level (log2 read counts): -0.13

Expression Distribution

Screen	Score
Menadione 5μM R06 exp292	-1.74
Zebularine 20μM R07 exp423	1.79
Tenofovir 10μM R07 exp405	2.18

CARD
NACHT

IPAF inflammasome complex
interleukin-1 beta secretion
pyroptosis
interleukin-1 secretion
detection of bacterium
detection of other organism
interleukin-1 beta production
interleukin-1 production
detection of external biotic stimulus
detection of biotic stimulus
cytokine secretion
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
cytokine production
positive regulation of cysteine-type endopeptidase activity
positive regulation of NF-kappaB transcription factor activity
protein secretion
establishment of protein localization to extracellular region
protein localization to extracellular region
positive regulation of endopeptidase activity
peptide secretion
positive regulation of peptidase activity
magnesium ion binding
regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cysteine-type endopeptidase activity
activation of innate immune response
positive regulation of DNA-binding transcription factor activity
defense response to bacterium
protein homooligomerization
positive regulation of innate immune response
positive regulation of proteolysis
positive regulation of response to biotic stimulus
regulation of endopeptidase activity
regulation of DNA-binding transcription factor activity
regulation of peptidase activity
regulation of innate immune response
positive regulation of defense response
inflammatory response
positive regulation of multi-organism process
protein complex oligomerization