NMD3 [The Human Chemical-Genetic Interaction Map Project]

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======= NMD3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NMD3
  * **<color #00a2e8>Official Name</color>**: NMD3 ribosome export adaptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51068|51068]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96D46|Q96D46]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NMD3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NMD3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611021|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NMD3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein localization to nucleolus|
|regulation of protein localization to nucleolus|
|ribosomal large subunit export from nucleus|
|ribosomal subunit export from nucleus|
|ribosome localization|
|ribosomal large subunit binding|
|rRNA-containing ribonucleoprotein complex export from nucleus|
|positive regulation of protein localization to nucleus|
|protein binding, bridging|
|positive regulation of protein binding|
|regulation of protein localization to nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|protein export from nucleus|
|nuclear export|
|positive regulation of binding|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|regulation of protein binding|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|ribosome biogenesis|
|positive regulation of cellular protein localization|
|establishment of organelle localization|
|regulation of binding|
|ribonucleoprotein complex biogenesis|
|regulation of cellular protein localization|
|organelle localization|
|nucleolus|
|regulation of cellular localization|
|intracellular protein transport|
|regulation of protein localization|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 666/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|23/28|
|bone|25/26|
|breast|29/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|19/21|
|liver|20/20|
|lung|72/75|
|lymphocyte|16/16|
|ovary|22/26|
|pancreas|24/24|
|peripheral nervous system|14/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1091
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NMD3 Expression in NALM6 Cells: 6.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>