NMD3

Entrez Summary: Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016].
UniProt Summary: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. {ECO:0000269|PubMed:12724356, ECO:0000269|PubMed:12773398}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 666/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	23/28
bone	25/26
breast	29/33
central nervous system	54/56
cervix	4/4
colorectal	16/17
esophagus	11/13
fibroblast	1/1
gastric	13/16
kidney	19/21
liver	20/20
lung	72/75
lymphocyte	16/16
ovary	22/26
pancreas	24/24
peripheral nervous system	14/16
plasma cell	11/15
prostate	1/1
skin	20/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	17/22
urinary tract	28/29
uterus	5/5

Expression Distribution

positive regulation of protein localization to nucleolus
regulation of protein localization to nucleolus
ribosomal large subunit export from nucleus
ribosomal subunit export from nucleus
ribosome localization
ribosomal large subunit binding
rRNA-containing ribonucleoprotein complex export from nucleus
positive regulation of protein localization to nucleus
protein binding, bridging
positive regulation of protein binding
regulation of protein localization to nucleus
ribonucleoprotein complex export from nucleus
ribonucleoprotein complex localization
RNA export from nucleus
protein export from nucleus
nuclear export
positive regulation of binding
nucleic acid transport
RNA transport
establishment of RNA localization
RNA localization
regulation of protein binding
nucleobase-containing compound transport
protein-containing complex localization
nucleocytoplasmic transport
nuclear transport
ribosome biogenesis
positive regulation of cellular protein localization
establishment of organelle localization
regulation of binding
ribonucleoprotein complex biogenesis
regulation of cellular protein localization
organelle localization
nucleolus
regulation of cellular localization
intracellular protein transport
regulation of protein localization
RNA binding
protein transport
intracellular transport