NOL7 [The Human Chemical-Genetic Interaction Map Project]

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======= NOL7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOL7
  * **<color #00a2e8>Official Name</color>**: nucleolar protein 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51406|51406]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UMY1|Q9UMY1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOL7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOL7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611533|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NUC129|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleolus|
|mitochondrion|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.92|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.82|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.76|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.7|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.75|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.77|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.95|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.461|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.439|
|[[:human genes:n:ncl|NCL]]|0.426|
|[[:human genes:k:kctd17|KCTD17]]|0.419|
|[[:human genes:r:rps2|RPS2]]|0.415|
|[[:human genes:a:akap1|AKAP1]]|0.412|
|[[:human genes:u:utp3|UTP3]]|0.411|
|[[:human genes:s:slc6a17|SLC6A17]]|0.41|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.408|
|[[:human genes:a:acsf2|ACSF2]]|0.405|
|[[:human genes:p:pwp2|PWP2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 98/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|2/28|
|bone|3/26|
|breast|2/33|
|central nervous system|7/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|2/20|
|lung|10/75|
|lymphocyte|2/16|
|ovary|4/26|
|pancreas|5/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|4/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1761
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOL7 Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>