NPEPPS [The Human Chemical-Genetic Interaction Map Project]

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======= NPEPPS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPEPPS
  * **<color #00a2e8>Official Name</color>**: aminopeptidase puromycin sensitive
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9520|9520]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55786|P55786]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPEPPS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPEPPS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606793|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501, ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184, ECO:0000269|PubMed:19917696}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|metalloaminopeptidase activity|
|aminopeptidase activity|
|peptide catabolic process|
|positive regulation of protein targeting to mitochondrion|
|regulation of protein targeting to mitochondrion|
|peptide binding|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of establishment of protein localization to mitochondrion|
|regulation of protein targeting|
|positive regulation of mitochondrion organization|
|positive regulation of intracellular protein transport|
|regulation of mitochondrion organization|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|positive regulation of intracellular transport|
|cellular response to oxygen levels|
|regulation of intracellular protein transport|
|protein polyubiquitination|
|positive regulation of cellular protein localization|
|response to hypoxia|
|regulation of intracellular transport|
|response to decreased oxygen levels|
|response to oxygen levels|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|peptide metabolic process|
|regulation of cellular protein localization|
|positive regulation of organelle organization|
|protein ubiquitination|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|protein modification by small protein conjugation|
|cellular amide metabolic process|
|zinc ion binding|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of protein localization|
|organonitrogen compound catabolic process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of organelle organization|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.87|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.82|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.79|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.79|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.76|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.75|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.66|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15370
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPEPPS Expression in NALM6 Cells: 7.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>