NPEPPS

Gene Information

Official Symbol: NPEPPS
Official Name: aminopeptidase puromycin sensitive
Aliases and Previous Symbols: N/A
Entrez ID: 9520
UniProt: P55786
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501, ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184, ECO:0000269|PubMed:19917696}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 5ng/ml R00 exp35	-1.87
Latrunculin-B 10μM R07 exp374	-1.82
Colchicine 0.009μM R05 exp215	-1.79
Staurosporine 0.02μM R08 exp524	-1.79
JQ1 0.8μM R08 exp435	-1.76
UMK57 1μM R01 exp59	-1.75
LB-100 4.1μM R02 exp72	2.66
LB-100 2μM R05 exp210	2.89

Global Fraction of Cell Lines Where Essential: 8/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 15370
Expression level (log2 read counts): 7.52

Expression Distribution

metalloaminopeptidase activity
aminopeptidase activity
peptide catabolic process
positive regulation of protein targeting to mitochondrion
regulation of protein targeting to mitochondrion
peptide binding
positive regulation of establishment of protein localization to mitochondrion
regulation of establishment of protein localization to mitochondrion
regulation of protein targeting
positive regulation of mitochondrion organization
positive regulation of intracellular protein transport
regulation of mitochondrion organization
cellular response to hypoxia
cellular response to decreased oxygen levels
positive regulation of intracellular transport
cellular response to oxygen levels
regulation of intracellular protein transport
protein polyubiquitination
positive regulation of cellular protein localization
response to hypoxia
regulation of intracellular transport
response to decreased oxygen levels
response to oxygen levels
positive regulation of protein transport
positive regulation of establishment of protein localization
peptide metabolic process
regulation of cellular protein localization
positive regulation of organelle organization
protein ubiquitination
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
protein modification by small protein conjugation
cellular amide metabolic process
zinc ion binding
regulation of cellular localization
protein modification by small protein conjugation or removal
positive regulation of transport
regulation of protein localization
organonitrogen compound catabolic process