NPPB [The Human Chemical-Genetic Interaction Map Project]

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======= NPPB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPPB
  * **<color #00a2e8>Official Name</color>**: natriuretic peptide B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4879|4879]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16860|P16860]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPPB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPPB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600295|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. {ECO:0000269|PubMed:1672777}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ANP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diuretic hormone activity|
|hormone receptor binding|
|receptor guanylyl cyclase signaling pathway|
|cGMP biosynthetic process|
|positive regulation of renal sodium excretion|
|positive regulation of urine volume|
|cGMP metabolic process|
|negative regulation of systemic arterial blood pressure|
|regulation of renal sodium excretion|
|regulation of urine volume|
|cyclic nucleotide biosynthetic process|
|cyclic purine nucleotide metabolic process|
|regulation of excretion|
|cGMP-mediated signaling|
|regulation of renal system process|
|regulation of vascular permeability|
|cyclic nucleotide metabolic process|
|negative regulation of blood pressure|
|body fluid secretion|
|regulation of systemic arterial blood pressure|
|hormone activity|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|neuropeptide signaling pathway|
|renal system process|
|negative regulation of vasculature development|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|vascular process in circulatory system|
|purine-containing compound biosynthetic process|
|cyclic-nucleotide-mediated signaling|
|regulation of blood pressure|
|negative regulation of cell growth|
|protein folding|
|negative regulation of growth|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|regulation of angiogenesis|
|purine ribonucleotide metabolic process|
|regulation of vasculature development|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|signaling receptor binding|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|purine-containing compound metabolic process|
|blood circulation|
|circulatory system process|
|regulation of cell growth|
|positive regulation of secretion|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|regulation of body fluid levels|
|regulation of anatomical structure size|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|regulation of system process|
|protein-containing complex|
|carbohydrate derivative biosynthetic process|
|regulation of growth|
|enzyme linked receptor protein signaling pathway|
|regulation of secretion|
|organophosphate metabolic process|
|negative regulation of developmental process|
|positive regulation of transport|
|carbohydrate derivative metabolic process|
|regulation of anatomical structure morphogenesis|
|nucleobase-containing compound biosynthetic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|organonitrogen compound biosynthetic process|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.85|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7027
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPPB Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>